Science NewsCurated by RSF Research Staff Home > Science News > Chiral water super-structure forms around DNA Researchers at the University of Notre Dame have observed for the first time a chiral water superstructure templated around a biomolecule. Although many studies have demonstrated the direct interaction of water with highly important macromolecules like DNA, the latest study is a final confirmation that water forms a unique and enduring super-structure around the DNA double helix -- stabilizing the molecular conformation, mediating its functionality and interaction with important information intermediaries like RNA polymerase. Taken in consideration with other recent reports, such as the direct mapping of molecular couplings and energy exchange between DNA backbone vibrations and water with femtosecond infrared spectroscopy, it is becoming increasingly difficult to ignore the central role of water in some of the most important of biological functions. Water forms hydration patterns around biomolecules via hydrogen bond interactions -- and is so crucial in organizing and orchestrating the cellular environment that researchers like Gerald Pollack have even highlighted its importance as the possible progenitor to the cellular membrane -- giving birth to the first cells of life. The latest study used coherent nonlinear vibrational microscopy for unprecedented vibrational imaging speeds and molecular spatial resolution, allowing DNA molecules and the associated hydration patterns of water to be observed in high detail at near-physiological conditions (room temperature and 100 mM NaCl solution). The research team found that DNA imprints its chirality (think left-handed versus right-handed orientations) on the surrounding water molecules, causing the formation of a macroscopic super-structure of water template along the DNA double helix. While it is known that the specific template patterning of water molecules along the DNA molecule is important for recognition of gene promoter sequences by interacting proteins (see for example the study 'interfacial water as a hydration fingerprint'), the complete biological relevance of a chiral spine of hydration is unknown. Although, it does lend support for controversial findings like that of Luc Montagnier -- in which the Nobel laureate and his research team, including the theoretical physicist Emilio Del Giudice who pioneered work on the quantum field theory of condensed soft matter, especially water -- performed a series of experiments that suggests DNA sequences can be reconstituted from water memory. The study is detailed in the report "transduction of DNA information through water and electromagnetic waves". The ability to directly detect water's interaction and pivotal role in biomolecular functions is an exciting development of advanced spectroscopic technologies and molecular biology and will provide revelatory insights into the biophysics and physico-chemical properties at the molecular level of life. When Szent-Gyorgyi called water the “matrix of life”, he was echoing an old sentiment. Paracelsus in the 16th century said that “water was the matrix of the world and of all its creatures.” But Paracelsus’s notion of a matrix -- an active substance imbued with fecund, life-giving properties -- was quite different from the picture that, until very recently, molecular biologists have tended to hold of water’s role in the chemistry of life. Although acknowledging that liquid water has some unusual and important physical and chemical properties -- its potency as a solvent, its ability to form hydrogen bonds, its amphoteric nature [a molecule that can react both as an acid and a base] -- biologists have regarded it essentially as the backdrop on which life’s molecular components are arrayed. It used to be common practice, for example, to perform computer simulations of biomolecules in a vacuum. Partly this was because the computational intensity of simulating a polypeptide chain was challenging even without accounting for solvent molecules too, but it also reflected the prevailing notion that water does little more than temper or moderate the basic physicochemical interactions responsible for molecular biology. What Gerstein and Levitt said 9 years ago remains true today: “When scientists publish models of biological molecules in journals, they usually draw their models in bright colors and place them against a plain, black background”. Curiously, this neglect of water as an active component of the cell went hand in hand with the assumption that life could not exist without it. That was basically an empirical conclusion derived from our experience of life on Earth: environments without liquid water cannot sustain life, and special strategies are needed to cope with situations in which, because of extremes of either heat or cold, the liquid is scarce. The recent confirmation that there is at least one world rich in organic molecules on which rivers and perhaps shallow seas or bogs are filled with nonaqueous fluid -- the liquid hydrocarbons of Titan -- might now bring some focus, even urgency, to the question of whether water is indeed a unique and universal matrix of life, or whether on the contrary it is just the one that happens to pertain on our planet. – Phillip Ball, Water as an Active Constituent in Cell Biology Article: http://pubs.acs.org/doi/pdf/10.1021/acscentsci.7b00100 Newly Released Report Examines Favourable and Unfavourable EMF Frequency Patterns in CancerApril 23, 2018Is Dark Matter Primordial Black Holes?April 20, 2018Plasmomechanical device modulates, transduces and amplifies lightApril 13, 2018Metamaterial device controls transmission and reflection of acoustic wavesApril 10, 2018Quantum Coherence Underlying Magnetoreception in Avian Species ConfirmedApril 6, 2018 Sharing is caring - please share this with your friends: Facebook Twitter If you like this content, you will love the Resonance Academy.